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Year : 2017  |  Volume : 4  |  Issue : 1  |  Page : 8-14

Microfluidics in andrology

1 Army Hospital (R&R), Delhi Cantt, India
2 Uttar Pradesh Technical University, Lucknow, Uttar Pradesh, India

Correspondence Address:
Pankaj Talwar
Army Hospital (R&R), Delhi Cantt 110010
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/fsr.fsr_4_18

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Male factor infertility is the sole cause of infertility in approximately 20% of the infertile couples with sperm playing a crucial role in the whole process of fertilization. Many technologies such as swim-up and density gradient techniques have been developed for the counting and sorting of sperms over the past few decades. Microfluidic technology was introduced into this field at the beginning of the 21st century. Studies have reported that conventional semen processing techniques have adverse effects on sperm deoxyribo nucleic acid (DNA) integrity leading to decreased pregnancy rates and are also associated with potential promutagenic alterations to sperm DNA. A gravity-driven microfluidic device, on the other hand, isolates motile sperms with good DNA integrity from seminal plasma, dead sperm, and debris, using microscale laminar flow without centrifugation. The objective of this review study is to evaluate whether microfluidic sperm sorters allow the effective recovery of sorted motile sperm without DNA damage compared with the centrifugation and swim-up procedure.

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