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Year : 2019  |  Volume : 6  |  Issue : 1  |  Page : 35-39

Addition of oestradiol to progesterone for luteal phase support in GnRh antagonist IVF/ICSI cycles

Medicover Fertility, Panchsheel Park, New Delhi, India

Correspondence Address:
Dr. Rachita Munjal
Medicover Fertility, Panchsheel Park, New Delhi
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/fsr.fsr_25_19

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Objective: Studies have found conflicting results with respect to the use of progesterone alone or oestrogen and progesterone as luteal phase support for in vitro fertilisation (IVF)/ICSI cycles involving use of GnRh antagonist. The purpose of the study is to determine the effect of luteal phase supplementation with oestradiol and progesterone versus progesterone alone in women undergoing IVF/ICSI-Embryo transfer (ET) in relation to the pregnancy rate. Design: This was a retrospective observational study spanning 1 year conducted at Medicover Fertility, New Delhi. A sample size of 150 women was taken. Materials and Methods: All women underwent controlled ovarian stimulation by gonadotropin and GnRh antagonist protocol. Oocyte retrieval was performed after 34 to 36 hours of hCG trigger and embryos were transferred 3 days after oocyte retrieval. According to luteal phase support protocol, two groups were made: study group (oestrogen plus progesterone, n = 75) and control group (progesterone alone, n = 75). Results: The study and control group did not differ for age, religion, duration of infertility, cause and type of infertility. Out of 75 women in the study group, 31 women conceived, the pregnancy rate being 41%. In the control group, 27 out of 75 women conceived, the pregnancy rate being 36%. Thus, the pregnancy rate was observationally higher in the study group, but the difference was not statistically significant (P value = 0.50). Conclusion: Giving oestradiol supplementation along with progesterone in the luteal phase did not improve pregnancy rates significantly. Further, more studies are required to see hormonal profile of oestradiol and progesterone levels during luteal phase and its correlation with pregnancy rate.

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