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Year : 2021  |  Volume : 8  |  Issue : 2  |  Page : 128-133

Maternal age and its impact on implantation and clinical pregnancy rates in patients undergoing day 3 versus day 5 embryo transfer in Indian population

Department of Clinical ART, Ridgeivs, Delhi, India

Correspondence Address:
Dr. Kumkum Rana
Department of Clinical ART, Ridgeivs, N-17 (1004), Jaypee Aman, Sector 151, Noida, Uttar Pradesh
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/fsr.fsr_28_21

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Objective: The present study compared the reproductive outcomes (implantation rate, pregnancy rate) between day 3 and day 5 transfers in two different age groups of patients (aged <36 years vs. aged ≥36 years). Materials and methods: The present study was conducted in the RIDGE IVF Centre, Gouri Hospital, New Delhi (India), after obtaining institutional ethical committee clearance. For frozen embryo transfers (FETs), day 3 embryos were thawed using Origio vitrification warming kit. The outcome parameters [anti mullerian hormone (AMH), antral follicle count (AFC), follicle-stimulating hormone, E2, mean number of oocytes retrieved, embryo grades A, B, and C, beta human chorionic gonadotropin (HCG), number of sacs, miscarriages, and live birth rate] were compared between age <36 versus >36 years, day 3 versus day 5 embryo, and fresh versus frozen embryo. The unpaired t test was used for comparing quantitative variables and Chi-squared test was used for comparing qualitative variables. Results: The mean age of the study population was 31.84 ± 3.74 years. The mean AMH, AFC, and oocytes retrieved were significantly more among <36 years compared to ≥36 years age group. Beta HCG and number of sacs did not differ between <36 years and ≥36 years age groups. The number of sacs formed and live birth were significantly more among frozen embryo. Day 5 embryo had significantly more positive rate of beta HCG, more number of sac formations, and live birth. Conclusion: The present study dictates that in vitro fertilization rate showed better success with women <36 years of age than >36 years old. Day 5 blastocysts had good implantation rates along with higher resulting pregnancy rates. The FET had better live birth rate.

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