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ORIGINAL ARTICLE
Year : 2021  |  Volume : 8  |  Issue : 2  |  Page : 134-138

Impact of modified intracytoplasmic sperm injection technique on in vitro fertilization outcomes


Center of IVF and Human Reproduction, Sir Ganga Ram Hospital, New Delhi, India

Correspondence Address:
Dr. Gaurav Majumdar
Center of IVF and Human Reproduction, Sir Ganga Ram Hospital, New Delhi 110060
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/fsr.fsr_23_21

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The objective of the study was to evaluate the impact of modified intracytoplasmic sperm injection (ICSI) technique on in vitro fertilization outcomes. The study was conducted in a tertiary infertility center, New Delhi. In this retrospective cohort study, we retrospectively analyzed 247 ICSI cycles. Different inclusion and exclusion criteria were applied to remove the biasness of study. The 247 ICSI cycles were divided into two groups. Group A (n = 152) in which the patient underwent through modified ICSI technique), Group B (n = 95) in which patient underwent conventional ICSI). Modified technique involves repeated in and out movements of the injection pipette to break the oolemma without applying negative pressure to reduce the detrimental effect on oocyte. Fertilization rate was found to be higher in modified ICSI group when compared with conventional ICSI (70% vs. 63%; P = 0.0006). The embryo utilization rate was found to be similar in both the groups (38.4% vs. 40.2%). The overall blastocyst utilization rate was also comparable between both the groups. The mechanical modification of not applying negative pressure during ICSI resulted in a significant increase in fertilization rate. A larger study is required to validate the technique in terms of other embryologic parameters.


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