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Year : 2021  |  Volume : 8  |  Issue : 2  |  Page : 173-179

Booster dose of human chorionic gonadotrophin for unruptured follicle in non-IVF/ICSI cycles: a randomized controlled study

1 Department of Obstetrics and Gynecology, Tanta University, Tanta, Egypt
2 Department of Obstetrics and Gynecology, Zagazig University, Zagazig, Egypt

Correspondence Address:
Dr. Ayman Shehata Dawood
Faculty of Medicine, Department of Obstetrics and Gynecology, Tanta University, Tanta, Gharbia
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/fsr.fsr_36_21

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Objectives: To assess the effect of booster dose of human chorionic gonadotropin (HCG) on the unruptured follicles in non-in vitro fertilization/intracytoplasmic sperm injection cycles. Setting and design: This randomized controlled multicenter study was conducted at Tanta and Zagazig University hospitals in the period from August 1, 2018 to January 1, 2021. Patients and methods: Enrolled patients (n = 160) who had unruptured mature Graafian follicle 48 hours after intramuscular (IM) 10,000 IU HCG dose. Patients were allocated randomly into intervention group and control group. In the intervention group, another booster dose (10,000 IU of HCG) was given IM, whereas in the control group, 1 mL normal saline was given IM. Study outcomes: Ovulation and pregnancy rates. Results: The number of cases who had follicular rupture was similar to those in the control group. The incidence of luteinized unruptured follicle (LUF) was nearly similar in both groups. No significant differences were noticed regarding pregnancy rates in both groups. Conclusion: Booster dose of HCG for unruptured follicles has no benefit in ovulation triggering nor in the prevention of LUF syndrome. There was no significant difference in pregnancy rates in both groups.

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