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Year : 2021  |  Volume : 8  |  Issue : 2  |  Page : 180-184

Role of endometrial receptivity array in recurrent implantation failure

Department of Reproductive Medicine, Bansal Hospital, Bhopal, Madhya Pradesh, India

Correspondence Address:
Dr. Richa Samadhiya
Department of Reproductive Medicine, Bansal Hospital, Bhopal, Madhya Pradesh
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/fsr.fsr_40_21

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Introduction: The endometrial receptivity array (ERA), a customized microarray, is an objective test to assess the endometrial receptivity status of infertile patients. It provides an opportunity to do personalized embryo transfer (pET) by synchronizing with each patient’s window of implantation (WOI) thereby increasing the success of treatment particularly in couples with recurrent implantation failure (RIF). Aim: To find out whether pET after ERA testing in couples with RIF improves implantation and pregnancy rates. Materials and methods: This is a retrospective analysis of women with a history of RIF undergoing further infertility treatment at our center. In this study, records of 34 women with history of RIF who consented to undergo ERA from July 2016 to July 2020 were analyzed. Results: Thirty-four women with RIF who underwent ERA testing showed receptive endometrium in 21 patients (61.8%) and nonreceptive endometrium in 13 (38.2%) patients. Of these, 27 patients were included for analysis and they underwent total of 31 embryo transfer cycles. ERA showed receptive endometrium in 17 patients and nonreceptive in 10 patients. Among eight women who had nonreceptive ERA result which means displaced WOI pET resulted in an implantation rate of 45.5% and pregnancy rate of 50% which was comparable to the 55.4% background pregnancy rate of the general in vitro fertilization population during the same time period. Conclusion: Hence, there is a subset of patients with RIF who can achieve a pregnancy rate as good as general population with pET based on ERA results and ERA can be recommended to such patients.

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