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Year : 2022  |  Volume : 9  |  Issue : 1  |  Page : 23-28

Influence of sperm morphology in ICSI cycle outcomes: a retrospective study

1 Sai College of Medical Science and Technology, Kanpur, Uttar Pradesh, India
2 Southend IVF & Fertility Center, 2 Palam Marg Vasant Vihar, New Delhi, India

Correspondence Address:
Sazda Khatoon
lauwan, Hardiya,via; Barhariya, Siwan, Bihar,.Pin Code 841232
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/fsr.fsr_17_21

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Aim: To determine whether sperm morphology has any influence on the assisted reproductive technique (ART) outcome in in vitro fertilization (IVF)-intracytoplasmic sperm injection (ICSI) cycles. Objectives: To assess whether sperm morphology affects IVF-ICSI outcome. Method: This study was a retrospective analysis of data from 1000 couples who had undergone ART cycle at Southend Fertility & IVF, Delhi between January 2016 and January 2021. The recruited patients were divided into two groups: Group A: Group A was the study group, and included 600 patients with an abnormal sperm morphology (morphology of <4%); Group B: Group B was the control group, and included 400 patients with a normal sperm morphology (morphology of >4%). The two groups were compared in terms of fertilization rate, embryo development rate, grade A embryo development rate, grade B embryo development rate, grade C embryo development rate, cleavage rate, embryo discarded or damage rate, and pregnancy rate. Results: Of the total 1000 ART-ICSI cycles analyzed the baseline characteristics, such as age, type of infertility, and semen parameters such as volume, count, motility, debris, agglutinations, grade A motility, grade B motility, total progressive (A+B) motility, morphology assessments, and type of protocol used for stimulation were comparable between the two groups. In the 1000 patients analyzed, a total of 6871 oocytes were injected at ICSI, of which 4049 oocytes belonged to group A and 2822 oocytes belonged to group B of the 6871 oocytes injected, 6275 got fertilized, giving a fertilization rate of 91.3%. On comparing the fertilization rate of the two groups, a fertilization rate of 90.1% (3650/4049) was observed in group A and 93.01% (2625/2822) was observed in group B, which was statistically different (P < 0.001). Of the various outcome parameters, a statistically significant difference was reported in the fertilization rate, cleavage rate, embryo development rate, grade A embryo development rate, and grade C embryo development rate in the two groups. No statistically significant difference was observed in the pregnancy rate. It was also observed that once fertilization occurred, embryo quality was good for all types of abnormal spermatozoa (grade A, good- to excellent-quality embryos), except for spermatozoa with broken necks, with which only good to excellent quality, or poor quality grade B and group C embryos were obtained. Conclusion: Sperm morphology influences the fertilization rate, cleavage rate, and the embryo development rate but there is no significant influence of sperm morphology on pregnancy rate.

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