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Year : 2022  |  Volume : 9  |  Issue : 1  |  Page : 51-54

Impact of peak serum estradiol levels on the outcomes of hormone replacement therapy (HRT) frozen embryo transfer (FET) cycles

1 Fellow in Clinical ART, Ridge IVF, Gouri Hospital, Delhi, India
2 Director, Ridge IVF, Gouri Hospital, Delhi, India
3 Clinical Director, Ridge IVF, Gouri Hospital, Delhi, India

Correspondence Address:
Priyanka Kalra
Fellow in Clinical ART, 2GF1, ATS Dolce, Zeta 1, Greater Noida, Uttar Pradesh 201310
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/fsr.fsr_5_22

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With the improvised ovulation induction methods coming up, FET (Frozen Embryo Transfer) has gained preference over fresh transfers. Several strategies have been devised for preparing the endometrium for FET, out of which the hormone replacement regimen (HRT) with exogenous estrogen and progesterone supplementation still remains the most popular one. There are different clinical protocols for the transfer of frozen-thawed embryos. However, there has always been a debate about the impact of hyperestrogenism on endometrial development and implantation, particularly when controlled ovarian hyperstimulation is used in conjunction with fresh embryo transfers. We conducted this study with an objective to investigate the impact of variable serum estradiol (E2) levels achieved in the late follicular phase on implantation and pregnancy outcomes of cryopreserved/thawed embryos transferred in programmed cycles with exogenous hormonal replacement.

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