• Users Online: 704
  • Home
  • Print this page
  • Email this page
Home About us Editorial board Ahead of print Current issue Archives Submit article Instructions Referee Resource Subscribe
Year : 2022  |  Volume : 9  |  Issue : 1  |  Page : 61-65

Medical management of ectopic pregnancy with two different regimens of methotrexate: A comparative study

1 Department of Obstetrics and Gynecology, Deen Dayal Upadhyay Hospital, New Delhi, India
2 Hamdard Institute of Medical Sciences and Research, New Delhi, India

Correspondence Address:
MD, MBBS Pinkee Saxena
Department of Obstetrics and Gynecology, Deen Dayal Upadhyay Hospital, Hari Nagar, New Delhi, Delhi 110064
Login to access the Email id

Source of Support: None, Conflict of Interest: None

DOI: 10.4103/fsr.fsr_7_22

Rights and Permissions

Background: The timely and early diagnosis of ectopic pregnancy has made medical management of ectopic pregnancy the preferred treatment. Methotrexate is used in various regimens to treat ectopic pregnancy. A study was carried out to compare the effectiveness of double-dose and single-dose methotrexate regimen in medical management of unruptured ectopic pregnancy. Materials and Methods: The study included 80 hemodynamically stable patients with unruptured ectopic pregnancy. They were then randomly assigned in to two groups. Group A patients received two doses of methotrexate 50 mg/m2 on day 1 and day 4 whereas group B patients received single dose 50 mg/m2 methotrexate on the day 1. Serum β human chorionic gonadotropin (β-hCG) and blood parameters were measured in both the groups on day 4 and day 7 followed by serial serum β-hCG weekly till negative value was obtained. Outcome measures were success rate of treatment, need for extra dose of methotrexate, need of laparotomy, and side effects of methotrexate. Results: The two groups were comparable in demographic parameters, baseline serum β-hCG, and blood parameters. The treatment success rate was slightly more in group A (70%) than group B (65%); however, it was statistically insignificant. Need of extra dose of methotrexate was 5% in group A and 17.5% in group B, respectively. Ten patients in group A and seven patients in group B underwent laparotomy for rupture of the ectopic mass. The reported side effects of methotrexate was comparable in both the groups. Conclusion: Study shows that double-dose methotrexate is as effective as single dose in the medical management of ectopic pregnancy. It has slightly better success rate though statistically insignificant, with less need for extra dose and less duration of follow-up.

Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)

 Article Access Statistics
    PDF Downloaded72    
    Comments [Add]    

Recommend this journal