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ORIGINAL ARTICLE
Year : 2022  |  Volume : 9  |  Issue : 2  |  Page : 105-110

Efficacy of Co-Q10, vitamin D3, selenomethionine, astaxanthin in reduction of sperm DNA


1 Research Scholar, Department of Biotechnology, BN University, Udaipur, Rajasthan, India
2 HOD, Department of Biotechnology, BN University, Udaipur, Rajasthan, India

Correspondence Address:
Dhiraj Singh Ranawat
Research Scholar, Department of Biotechnology, BN University, Udaipur, Rajasthan
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/fsr.fsr_16_22

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High sperm DNA fragmentation can cause decreased fertility and implantation rate or can cause recurrent implantation failure. If fetus is born, it can lead to genetic abnormalities in the fetus such as Down syndrome, Edward syndrome, or Patau syndrome revealed by Schlegel.[1] The mechanisms examined include: apoptosis in the seminiferous tubule epithelium, defects in chromatin remodeling during the process of spermiogenesis, oxygen radical-induced DNA damage during sperm migration from the seminiferous tubules to the epididymis, the activation of sperm caspases and endonucleases, damage induced by chemotherapy and radiotherapy, and the effect of environmental toxicants. The objective of the study is to evaluate the efficacy of the combination of coenzyme-Q10 (Co-Q10) (100 mg), vitamin D3 (2000 I.U.), selenomethionine (400 mcg), astaxanthin (8 mg) tablet in reduction of sperm DNA fragmentation in males who visited the hospital. The result shows that factors affecting men with high levels of DNA fragmentation will have significantly lower odds of conceiving naturally or through procedures such as intrauterine insemination and IVF. Therefore, in men with high levels of DNA fragmentation, reduced with age and were found to have improvement with 6% to 7% in the age group 30 to 40, > 40 respectively. The Institutional Ethics Committee approved the study procedure (Ref No: SRMC/RP/4505). Context: Aim The aim of the study is to evaluate the effect of combination of Co-Q10 (100 mg), vitamin D3 (2000 I.U.), selenomethionine (400 mcg), astaxanthin (8 mg) on sperm DNA fragmentation index (DFI). Settings and Design: A type of prospective cohort study in which health conditions are measured before and after the treatment. Methods and Material: Patients were recruited after obtaining a written informed consent. On first visit, patient information was taken according to patient information sheet. Patients were counseled to take medication containing antioxidant and vitamin (Co-Q10, vitamin D3, selenomethionine and astaxanthin) for 3-month duration, twice-daily according to general information sheet and fill IPCC (Investigational product compliance card). On the next visit after 3 months, patient information is recorded; and semen examination and sperm DFI were done to note any changes. Statistical analysis used: To calculate sample sizes for comparing two means, we have taken confidence interval 95%, power 80%, and ratio of sample size for before and after group as 1. Mean and standard deviation were taken from published data for both the groups as 22.1 ± 7.7 before treatment and 9.1 ± 7.2 after treatment. Results: The percent wise distribution of infertile patients was 31.84%, 31.92%, 31.46% from the age group 20 to 30, 30 to 40, and > 40. The maximum number of patients were from the age group 30 to 40 and > 40; hence, control patients were selected from the same age group with percentage 25.01% and 25.35%, respectively. Conclusions: Efficacy of Co-Q10, vitamin D3, astaxanthin, and selenomethionine combination in male subjects with raised sperm DFI improved the outcome of assisted reproductive technique. There is decrease in DFI measured in percentage after giving CoQ, which was significant.


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