| ORIGINAL ARTICLE |
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| Year : 2022 | Volume
: 9
| Issue : 2 | Page : 111-118 |
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Does dual trigger with gonadotropin-releasing hormone agonist and low-dose human chorionic gonadotropin improves clinical outcomes in normal responders in gonadotropin-releasing hormone (GnRH) antagonist IVF-ICSI Cycles
Kanad Dev Nayar, Shweta Gupta, Sabina Sanan, Sumita Agarwal, Gaurav Kant, Kapil Nayar
Akanksha IVF Centre, Mata Chanan Devi Hospital, New Delhi, Delhi, India
Correspondence Address:
Kanad Dev Nayar
Chief Consultant & HOD, Mata Chanan Devi Hospital, C-1 Janakpuri, New Delhi, Delhi
India
 Source of Support: None, Conflict of Interest: None  | Check |
DOI: 10.4103/fsr.fsr_23_22
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Objective: To study and compare the effectiveness of dual trigger with gonadotropin-releasing hormone agonist (GnRHa) and low dose human chorionic gonadotropin (hCG) for final oocyte maturation versus human chorionic gonadotropin trigger for improving clinical outcomes in GnRH Antagonist IVF-ICSI Cycles in normal responder patients. Materials and Methods: A prospective comparative study was conducted at a tertiary care infertility centre. Eighty (80) normoresponders who were to undergo IVF-ICSI cycles were included in the study. Patients in both groups underwent controlled ovarian hyperstimulation using GnRH antagonist protocoI. Group 1/Study (n = 40) patients were given Inj Leuprolide acetate and low dose highly purified injection hCG. Group 2/ control group received standard dose of highly purified injection hCG. Day 3 fresh embryo transfers were performed. Primary outcome measured was clinical pregnancy rate and secondary outcomes measured were: implantation rate, miscarriage rate, number of MII oocytes, number of embryos formed, risk of OHSS. Results: In group 1 the clinical pregnancy rate and implantation rate were higher than in group 2, 52.50% vs 47.50% and 29.67% vs 26.08% but the difference was not statistically significant. There were significantly higher number of MII oocytes retrieved (10.63±5.46 Vz 8.10±5.74) and higher number of embryos formed (8.2±3.4 Vz 6.8±3.6) in group1 than in group 2. Conclusion: Though there was increased clinical pregnancy rate and implantation rate in dual trigger group but it was not statistically significant. There was significant increase in MII oocytes and number of embryos formed in the dual trigger group.
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