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Year : 2022  |  Volume : 9  |  Issue : 2  |  Page : 119-123

Impact of day 5 vs. day 6 blastocyst transfer on the pregnancy outcome of frozen-thawed donor recipient cycles

Centre of IVF and Human Reproduction, Sir Ganga Ram Hospital, New Delhi, India

Correspondence Address:
Shweta Mittal
Centre of IVF and Human Reproduction, Sir Ganga Ram Hospital, New Delhi
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/fsr.fsr_18_22

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Objective: To compare pregnancy outcome and early pregnancy loss in day 5 versus day 6 frozen-thawed donor recipient embryo transfer cycles. Methods: 414 consecutive donor recipient cycles were analysed who had undergone frozen-thawed elective single blastocyst transfer cycles (FET), were non-preimplantation genetic tested (PGT) embryos. High-grade blastocysts were vitrified on day 5 (n = 335) or day 6 (n = 79). Post embryo transfer progesterone supplementation was commenced when endometrial thickness >7 mm was reached after hormone replacement. Frozen blastocysts thawed were assessed for survival, clinical pregnancy, and early pregnancy in both the groups (day 5 [Group A] versus day 6 [Group B]). Statistical analysis was done using chi-square test. Results: All parameters like mean age of oocyte donor (25.03 vs. 24.97 years, p = 0.986), endometrial thickness (8.06 mm vs. 8.23 mm, p = 0.961), and embryo survival (97% vs. 98%, p = 0.776) were comparable in both the groups. Clinical pregnancy rate was found to be similar between Group A versus Group B (50.74% vs. 49.36%, p = 0.825, OR 1.05, CI 0.645–1.724). Clinical miscarriage rate in Group B was 33.33% as compared to 17.05% in Group A, p = 0.022, OR 2.43, CI 1.12–5.28) and was statistically significant. Conclusion: Pregnancy potential of high‐grade blastocysts frozen on day 5 or day 6 seems to be comparable. Younger age of donors had low expected pregnancy loss rates; however, the miscarriage rate was significantly higher in day 6 embryos. Thus, raises an important question if these cycles would perform better if PGT-A is offered when only day 6 embryos are available for transfer.

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