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Year : 2022  |  Volume : 9  |  Issue : 2  |  Page : 80-86

GnRH agonist trigger in modern reproductive medicine practice − when, why, and how?

1 Senior Clinical Fellow in OBGY, Manchester University Hospitals NHS Trust, Manchester, UK
2 Specialty Doctor in OBGY, Manchester University Hospitals NHS Trust, Manchester, UK
3 Consultant in Reproductive Medicine, Manchester University Hospitals NHS Trust, Manchester, UK

Correspondence Address:
Deepti Gupta
10 Ripon Groove, Sale, M33 5GZ, Manchester, United Kingdom
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/fsr.fsr_26_22

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The use of gonadotropin-releasing hormone (GnRH) antagonist protocols in assisted conception is a major advance in modern reproductive medicine practice. Specifically, the application of GnRH agonist (GnRHa) as the final trigger for oocyte maturation in cycles where GnRH antagonist has been used is associated with a significant reduction in the risk of developing one of the most serious iatrogenic complications of assisted conception, ovarian hyperstimulation syndrome. GnRHa trigger has been shown to be as effective as human chorionic gonadotropin trigger with respect to oocyte yield and maturity in both autologous and donor cycles in multiple studies. This trigger, however, results in poor corpus luteum development and consequently luteal phase dysfunction and impaired endometrial receptivity. In this review, we address the indications, contraindications, outcomes, and practical considerations when using the GnRHa trigger.

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